*******************************************************************************************
Skills Summary:
* Three years experience in membrane biophysics (lipid chemistry, membrane fusion, drug encapsulation, peptide/lipid interactions).
* Two years experience in Structural Biology (protein/peptide conformation).
* Four and half years experience in Colloid Chemistry (micelle, emulsion, polymer-surfactant interaction). Chemist with a strong working background in lipids, surfactants and polymer chemistry.
* Spectroscopic Techniques: Steady State Fluorescence, Time-resolved Fluorescence, 2D NMR, Ultraviolet and Visible Absorption, and Light scattering.
* Others: Water's Gel Permeation Chromatography (GPC), High Pressure Liquid Chromatography (HPLC), Tensiometry, Titration Calorimetry and Conductometry.
* Well conversant with computer application softwares (microsoft word, sigma plot, origin, excel, power point, page maker etc).  Experienced with Silicon Graphic, Indigo 2.
* Team worker, enthusiastic, able to work under pressure and attractive to detail.

Current Research:  Peptide-lipid interactions, molecular mechanism of membrane fusion, fusion assay development, preparation and characterization of leakage free liposome.

Future Research interests: protein/peptide-lipid interactions, lipid-surfactant interactions, protein mediated membrane fusion, drug delivery, anti viral drug design and structural biology of fusion proteins/peptides.

Education:
* Ph. D. in Physical Chemistry, 1996, Jadavpur University, Calcutta
* M. S. in Physical Chemistry, 1991, Calcutta University, Calcutta
* B. S. in Chemistry (major)/Physics & Mathematics (subsidiary), 1989, Calcutta University, Calcutta.

Scholarships:
* Fellowship from Indian Association for the Cultivation of Science, Calcutta, India.
* Fellowship from Saha Institute of Nuclear Physics, Calcutta, India, Department of atomic Energy.
* Fellowship from Academia Sinica, Taiwan.
* Fellowship from NIH, USA.

Professional Memberships:
Member: Biophysical Society, Life member: Indian Association for the Cultivation of Science.

Professional Experience:
* 1998 June-present: Post Doctoral Research Associate, University of North Carolina, Department of Biochemistry & Biophysics, Chapel Hill, NC-27599, USA.
Preparation and characterization of leakage free liposomes and encapsulation of drug like molecules.  Development and design of new lipid mixing assay.  Details molecular mechanism of membrane fusion in presence of peptides (HA and HIV) and poly(ethylene glycol) based on time kinetics and proposed a novel hypothesis for membrane fusion events.

* 1997 Sept.-1998 May: Post Doctoral Research Associate, Institute of Chemistry, Academia Sinica,Taipei, Taiwan.
Synthesized two short chain peptides representing HIV protein and influenza respectively using automatic protein synthesizer and purified by HPLC.  Structural changes occurred during membrane binding was determined by NMR, CD and fluorescence.  A novel model was proposed for understanding the mechanism of membrane fusion by HIV protein.

* 1996 Nov.-1997 Sept. : Post Doctoral Research Associate, Saha Institute of Nuclear Physics, Department of Nuclear Chemistry 1/AF Bidhannagar, Calcutta-700-064.
Structural biology of proteins (HRP, HSA) in presence of denaturants.  A detailed study was carried out to understand the role of denaturants in protein folding.
Developed a novel method for determining the hydrophobic pocket of protein by pyrene fluorescence

* 1991 Dec.-1996 Oct. : Ph.D. work, Indian Association for the Cultivation of Science, Polymer Science Unit,  Jadavpur, Calcutta-700-032, India.
Surfactants and Polymer Chemistry, Dissertation: "Physicochemical properties of Mixed Micelle Formation and Polymer Surfactant Interaction".  Extensive studies on surface and bulk properties (CMC, polarity, aggregation number, area per surface active molecules, surface excess, thermodynamics of micellization and adsorption) of mixed surfactant and polymer-surfactant systems.

References:
1. Prof. Barry R. Lentz, Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC-27599, USA. Tel: 919-966-5384, Email: uncbrl@med.unc.edu
2. Dr. Abhijit Chakrabarti, Biophysics Division, SINP, Calcutta-700037, Tel: 91-33-337-4637, Email: abhijit@biop.saha.ernet.in
3. Prof. S.P. Moulik, Center for Surface Science, Department of Chemistry, Jadavpur University, Calcutta-700032,
Tel: 91-33-483-8411, Email: spmcss@yahoo.com

Papers presented in National/International Symposium:
*   45th Annual Biophysical meeting at Boston, Massachusetts, Feb. 17-21, 2001, Biophysical J, vol. 80,
     419A.
*   44th Annual Biophysical meeting at New Orleans, Feb 12-16, 2000,  Biophysical J.,   78, 57A.
*   National Conference on Solution Chemistry, Visva Bhariti, Santiniketan, 1994, January.
*  International Symposium on Surface and Colloid Science and its Relevance to Soil Pollution and 6th  National   Conference on Surfactant, Emulsion and Biocolloids, Madras, 1994, March.
*   International Symposium on Macromolecules, Thiruvanathapuram, 1995, January.
*   National Conference on Science and Technology of Self Organizing Systems with Especial Reference to New Generation Surfactants, Jadavpur University, Calcutta, 1995, September.
*  International Symposium on Micelles, Microemulsions and Monolayers. Quarter Progress & New Horizons, Florida, USA, 1995, August.

List of Publications:
1. Haque, M.E., McCoy, A.J., Glenn, J., Lee, J. and Lentz, B.R. “Effect of hemagglutinin fusion peptide on PEG-mediated fusion of phosphatidylcholine vesicles” (2001) Biochemistry (in press).
2. Malinin V.S., Haque, M.E. and Lentz, B.R “The Rate of Lipid Transfer During Vesicle Fusion Depends on the Structure of Fluorescent Lipid Probes: A New Chain-Labeled Lipid Transfer Probe Pair” (first two authors contributed equally to this work), (2001) Biochemistry 40, p-8292.
3. Haque, M.E., McIntosh,T.J. and Lentz, B.R. “Influence of Lipid Composition on Physical Properties and Poly(ethylene glycol) mediated Fusion of Curved and Uncurved Model Membrane Vesicles”: Nature’s Own Fusogenic Lipid Bilayer (2001) Biochemistry 40, p-4340.
4.  Lentz, B.R., Malinin, V.S., Haque, M.E. and Evans, K.O. “Protein Machines and Lipid Assemblies:  Currents Views of Cell Membrane Fusion” (2000) Current Opinion in Structural Biology 10, p-608.
5. Basak,  S., Debnath, D., Haque, M.E., Ray, S. and Chakrabarti, A. “Structural Perturbation of Proteins   in Low Denaturant Concentrations” (2001) Ind. J. Biochem. Biophys. 38, p-84.
6.  Haque, M.E., Ray, S., and Chakrabarti, A. "Polarity Estimate of the Hydrophobic Binding Sites in Erythroid Spectrin: A Study by Pyrene Fluorescence" (2000) J. of Fluorescence 10, p-1.
7.  Haque, M.E., Debnath, D., Basak, S., and Chakrabarti, A. "Structural changes in Horseradish Peroxi-dase in Presence of Low Concentration of Urea" (1999) Eur. J. Biochem. 259, p-269.
8. Haque, M.E., Das, A.R., and Moulik, S.P. "Mixed micelles of Dodium Deoxycholate and Polyoxyethylene Sorbitan Monooleate (Tween 80)" (1999) J. Colloid and Interface Sci. 217, p-1.
9.   Das, A.R., Haque, M.E., Dasburman, A., Ghosh, S., and Basu, S.N.  "Mixed Micelles of Sodium   Glycodeoxycholate (NaGDC) and  Polyoxyethylene Tert Octylphenyl Ether (Triton-x 100)" (1998)  J. Surf. Sci. Technol. 14, p-41.
10. Haque, M.E., Das, A.R., Rakshit, A.K., and Moulik, S.P. "Properties of Mixed Micelles of Binary Surfactant Combinations"  (1996) Langmuir 12, p-4084.
11. Moulik, S.P., Haque, M.E., Jana, P.K., and Das, A.R. "Micellar Properties of Cationic Surfactants in Pure and Mixed states" (1996) J. Phys. Chem. 100, p-701.
12. Haque, M.E., Das, A.R., and Moulik, S.P. "Behaviors of Sodium Deoxycholate (NaDC) and Polyoxyethylene Tert Octylphenyl Ether (TX-100) at the Air/Water Interface and in the Bulk" (1995) J. Phys. Chem. 99, p-14032.
13. Datta, A.K., Ray, T.K., Mandal, T.K., Haque, M.E., and Misra, T.N. "A Fluorescence Study of Naphthalene Tagged Polyvinylalcohol  assembled in Langmuir-Blodgett Films Mixed with Stearic Acid" (1995) Optical Materials 4, p-609.
14. Haque, M.E., Das, A.R., and Moulik, S.P. "Behaviors of Sodium Taurodeoxycholate (NaTDC) in presence of Poly(vinyl pyrolidone) in Aqueous Medium" Langmuir (under consideration).
15. Haque, M.E,. Chakrabarti, A., and Basak, S. "Structural Changes of Human Serum Albumin in Presence of Low Concentrations of Denaturants” (submitted).
16. Haque, M.E., Das, A.R., and Moulik, S.P. "Interfacial and Bulk interaction of Sodium Taurocholate (NaTC) and TX-100 in Aqueous Medium" (under preparation)
17. Haque, M.E. and Lentz, B.R. “Influence of GP41 fusion peptide on the kinetics of PEG-mediated model membrane fusion” (submitted).
18. Haque, M.E. and Lentz, B.R. “Relation Between Bilayer Properties and Structures of HA and HIV Fusion Peptide-Membrane Complexes” (manuscript under preparation).